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Graphical presentation of CX-5461-mediated activation from the cytosolic DNA sensing pathway. cGAS binding on the cytosolic DNA activates the secondary messenger two,3-cGAMP applying cGAS as being a catalyst. Activated STING buds off the ER shifting to your perinuclear Golgi, where by it's palmitoylated.[167] The Boulton Paul Defiant, Even with its